People with Angelman syndrome have a psychodynamic profile which is distinct from that of other similar conditions. Based on clinical observations and on standardized testing, receptive language skills are stronger than expressive, though many tasks required on traditional assessment techniques are made difficult by ataxia. There is an association between the underlying genetic diagnosis and developmental stage.
Motor skills are clearly affected in Angelman syndrome, and motor deficiencies are also reliably detected in mouse models. There is a delay in acquisition of motor milestones, with a genotype-phenotype correlation. People with Angelman syndrome often exhibit a characteristic broad-based jerky gait, associated with uplifted and bent arms.